박문호의 베스트북
산소
닉 레인
카탈라제
활성산소
과산화수소
2011.08.22 00:04:55
역시 World best!
'박문호의 베스트북'은 한권 한권, 모두 World best다!
감안하고 감안하고 또 감안해서 볼 일이다.
엄청난 자재력으로
응축해 표현해 주시는 소개말은 거의 화두다!!
그리고
'박문호의 베스트북' 자체가
이 사회에 던지는 화두다!!
2011.08.29 17:48:58
산소
산소 하면 100% pour가 무조건 건강에 100% 좋은 줄 알았다
태고적 0%가 있었던 시절
그래서 21%산소가 우리에게 주는 의미
활성산소
산소를 바로 알 수 있는 책..
이 책의 부제가 "세상을 만든 분자"입니다.
정말로 산소가 세상을 만들었을까요?
닉레인의 역작입니다.
이 책과 "미토콘드리아"는 짝꿍입니다.
닉레인은 영국 런던 대학(University of London)의 임페리얼 칼리지(Imperial College)에서 생화학을 전공했다. 왕립 자유 병원(Royal Free Hospital)에서 「장기 이식에 있어 자유 라디칼과 대사 기능에 대한 연구」로 박사 학위를 받았고 『사이언티픽 아메리칸』(Scientific American), 『란셋』 (The Lancet), 『영국 의학 저널』(British Medical Journal) 등 수많은 국제 학술지에 논문들을 발표했다. 유니버시티 칼리지 런던(University College London)의 명예 연구원이며, 런던의 의학 멀티미디어 회사인 Adelphi Medi Cine의 전략 이사로서 쌍방향 의학 교육을 개발하고 있다.
정말 좋은 책이고 많은 것을 제대로 차례대로 알게해주는 것 같은 책이다.
이전에 리뷰한 사람에게는 죄송하지만 30번을 읽어도 질리지는 않는다. -독자리뷰
Customer Reviews
(TOP 500 REVIEWER) (REAL NAME)
Doctor Lane's own background is in biochemistry, and his research focus has been on oxygen free radicals and metabolic function in organ transplants. Not surprisingly he went into some detail about the free radical cascade that affects cellular metabolism and DNA integrity. I found this somewhat difficult to understand as I have only a very rudimentary grounding in organic chemistry. Still I have to admit that I know somewhat more about the process than I did before reading this book.
Probably because I know significantly more about geology and paleontology, I enjoyed more fully the author's synthesis and analysis of what we know of the geological and biological development of our atmosphere and our planet. Some of this material was familiar to me from other sources: Certainly that O2 can actually be a "poison" I know from managing patients with ARDS (adult respiratory distress syndrome) on mechanical ventilators with 100% O2; that the earth went through a series of green house earth/snowball earth phases early in its history I had learned from Ward and Brownlee's book Rare Earth; that life had begun almost as early as it was able and much earlier than had been previously believed, I was aware of from works by Gould, Schopf, and others; and that the mitochondria may once have been free-living, aerobic organisms that formed a symbiotic relationship with anaerobic organisms was known to me from my past exposure to microbiology in a nursing class.
New to me however, was the concept that gigantism may have been a means of limiting the negative effects of a periodic increase in oxygen in the environment, as Dr. Lane suggests in his chapter on The Bolsover Dragonfly. Although I had read an article that suggested that the immense sizes achieved by some of the dinosaur species might have been due to a higher percent of O2 at the time, I had also understood that it was because oxygen was a "good" thing, an opportunity of sorts. Lane points out that the negative effects of oxygen on tissues and DNA through the free radical cascade might have been ameliorated by an increased size. An animal--or one presumes also a plant--that increased its size might have been able to distribute negative effects over a greater body mass. One wonders if the rise of the mammalian mega fauna of the ice ages and their sudden almost catastrophic disappearance might not also have been due to some temporary fluxuation in the oxygen level of their atmosphere. (In which case the early Native Americans could be once and for all exonerated of having liquidated them, since their demise would have been dictated by a return to a baseline oxygen level!) If this were the case, one might also question what type of changes might be expected among our own kind as a result of such an increase and decrease of atmospheric oxygen.
I found the doctor's ideas on the trade off between sexual reproduction and immortality a unique approach to the topic of aging. Some of this information--the studies of animal reproduction rates, predation, and age at death, for instance--was known to me. Dr. Lane's discussion brought it together in a much more complete way.
Certainly the concept of sexual reproduction being one of life's mechanisms of perpetuating the fragile, complex organic molecules (DNA) in an oxidative environment was interesting. I had read Ridley's proposal that sexual reproduction evolved as a means of resisting bacterial infection, but Lane's suggests why it began as early as the DNA swapping behavior among early single eukaryotic cells. That the massive increase in biological diversity was an indirect product of the release of oxygen into the atmosphere, is truly an amazing thought. In the event as Lane makes claim in his subtitle, oxygen was truly "The Molecule that made the World."